Fluoride is a ubiquitous element having many biological functions. The human body stores fluoride in the bones as a reservoir and releases the stored fluoride in an effort to maintain adequate fluoride for physiologic needs. Fluoride also incorporates into many molecules of the body replacing the hydroxyl radical thereby significantly increasing the biological activity of the molecule. The known functions of fluoride in the body are as follows:
Prevention of tooth decay (caries) 1
Stimulation of cells that produce bone (osteoblasts)2,3
Increases production of antibodies4
Causes death (apoptosis) of cancer cells6,7
Prevents chromosome damage preventing mutation8
Increases bone volume and bone density9,10
Increases bone and bone density in bone grafts11,12
As fluoride intake increases cancer incidence decreases significantly13
As fluoride intake increases heart disease incidence decreases14
Essential F contains 4.48 mg of fluoride per capsule to ensure you receive the minimum amount of fluoride as advised by the Food and Nutrition Board (FNB) of the Institute of Medicine. As outlined in an article published in Medical Hypotheses, Steiner Laboratories contends that fluoride is a nutritional requirement for normal human physiology. When an inadequate amount of fluoride is consumed disease develops. Tooth decay and cancer are very low in areas with very high fluoride in the water supply (NE Africa, Middle East, India and SE Asia). Areas with low fluoride concentration in the water have high tooth decay and high cancer incidence (North America and Europe). Essential F is formulated to provide a similar amount of fluoride that is contained in one liter water (approximately one quart) in areas with very low tooth decay and very low cancer incidence rates. Essential Fluoride taken daily will maintain a blood level of fluoride that is well within the normal physiological threshold of 190 ug/ml15.
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Directions and Dosage:
Adults only. Keep out of reach of children. Adults take one capsule per day.
Each capsule contains:
Active ingredients: 4.48 mg. fluoride
Inactive ingredients: microcrystalline cellulose, gelatin, 5.52 mg. sodium
Each order is a one month dose of 30 capsules
1 American Dental Association http://www.ada.org/public/topics/fluoride
2 Briancon D, Meunier PJ, 1981 Treatment of osteoporosis with fluoride, calcium, vitamin D. Orthop Clin North Am 12:629-648.
3 Harrison JE, McNiell KG et al 1981 Three-year changes in bone mineral mass of osteoporotic patients based on neutron activation analysis of the central third of the skeleton. J Clin Endocrinol Metab 52:751-758.
4 Butler JE, Satam M, Ekstrand J. Fluoride: an adjuvant for mucosal and systemic immunity. Immunol Lett. 1990 Dec;26(3):217-20.
5 Mangi SL, Summer WA, Phillips RW, Swartz ML. Antibacterial action of certain fluoride-containing dental restorative materials. J Dent Res. 1959 Jan-Feb;38(1):88-95.
6 Hirano S, Ando M. Fluoride mediates apoptosis in osteosarcoma UMR 106 and its cytotoxicity depends on the pH. Arch Toxicol 1997;72(1):52-8.
7 Anuradha CD, Kanno S, Hirano S. Fluoride induces apoptosis by caspase-3 activation in human leukemia HL-60 cells. Arch Toxicol 2000;74(4-5):52-8.
8 Vogel E. Strong antimutigenic effects of fluoride on mutation induction by trenimon and 1-phenyl-3,3-dimethyltriazene in Drosophila Melanogaster. Mutation Research1973;20:339-352.
9 Pak CY, Sakhaee K, Adams-Huet B, Piziak V, Peterson RD, Poindexter JR. Treatment of postmenopausal osteoporosis with slow-release sodium fluoride. Final report of a randomized controlled trial. Am Intern Med. 1995 Sep 15;123(6):401-8.
10 Reginster JY, Meurmans L, Zegels B, Rovati LC, Minne HW, Giacovelli G, Taquet AN, Setnikar I, Collette J, Gosset C. The effect of sodium monofluorophosphate plus calcium on vertebral fracture rate in postmenopausal women with moderate osteoporosis. A randomized, controlled trial. Ann Intern Med. 1998 Jul 1;129(1):1-8.
11 Stabholz A, Brayer L, Gedalia I, Yosipovitch Z, Soskolne WA. Effect of fluoride on autogenous iliac cancellous bone grafts and marrow transplants in surgically created intrabony defects in dogs. J Periodontol. 1977 Jul;48(7):413-7.
12 Nishino T. Nippon Seikeigeka Gakkai Zasshi. Experimental study on hydroxyapatite soaked in sodium fluoride--with special reference to bone formation.1991 Dec;65(12):1199-1210.
13 Steiner GG. Cancer incidence rates and environmental factors: An ecological study. Journal of Environmental Pathology, Toxicology and Oncology 2002;21(3):205-212.
14 Recent study conducted in Finland not yet published.
15 Gitomer WL, Sakhaee K, Pak YC. A comparison of fluoride bioavailability from a sustained-release NaF preparation (Neosten) and other fluoride preparations. J clin Pharmacol 2000;40:138-141.