 TISSUE ENGINEERING THE REGENERATION OF BONE
REGEN BIOCEMENT is a grafting material approved by the FDA for use in the maxillofacial region. REGEN BIOCEMENT has enabled the creation of new surgical procedures, such as the Steiner Sinus Lift, which allows practitioners to provide a previously unattainable level of care for their patients.
Steiner Laboratories developed Regen Biocement to bring the science of tissue engineering to clinical practice. Tissue engineering is the practice of replacing lost tissue or organs by introducing biologically active products to stimulate regeneration in a synthetic matrix designed to organize tissue growth.
The tissue engineering of bone requires the biologic stimulation of host cells. Due to the short half life of growth factors when placed in the graft site and the inability of a single growth factor to orchestrate the complex temporal and spatial molecular reactions needed to produce tissue, the use of single growth factors for the biologic stimulation of host cells produces only limited bone growth. For these reasons, Regen Biocement does not use growth factors, but instead contains SL Factor which stimulates the cell to increase the production of growth factors and other signaling molecules. SL Factor is time released as Regen Biocement is degraded. SL Factor enters the osteoblast and stimulates the osteoblast to produce the required signaling molecules and growth factors for bone production. SL Factor is transported across the cell membrane and into the nucleus, where it has been shown to modify the activity of over 300 genes and to produce an up-regulation in genes known to stimulate bone formation and a down-regulation in genes that facilitate bone loss. SL Factor stimulates mesenchymal stem cells to differentiate into osteoblasts and increases the production of alkaline phosphatase. SL Factor creates a two-fold increase in BMP2 and Runx2 production and reduces osteoclast formation by inhibiting the production of RANK ligand. In addition, SL Factor is stored in the osteoblast and continues to stimulate bone growth after the synthetic matrix has been resorbed.
The tissue engineering matrix of Regen Biocement was developed to provide a timed release of SL Factor as the matrix is resorbed. The matrix is a dual phase calcium phosphate biocement. The first phase sets quickly to provide body for the graft material. The second phase of the matrix sets over the following days and the first phase washes out - resulting in a porous matrix. The matrix is then resorbed as cells populate the matrix and provide calcium and phosphate compounds for the mineralization process. The matrix is non-ceramic, and therefore, does not inhibit bone formation. Additionally, the matrix is completely resorbed in approximately 2 months. |
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| PRICING |
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Each 2cc unidose syringe of Regen Biocement is priced at $60.
To order online click here or call (808) 689-1710 |
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| PREPERATION IS QUICK AND EASY |
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REGEN BIOCEMENT IS SUPPLIED IN A 2CC UNIDOSE SYRINGE |
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| Instructions for Unidose Syringe |
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| Open blue valve, push liquid into powder, mix back and forth until reaching a paste consistency and finish with graft material in one syringe. Allow mixed graft material to set for 3 minutes. After 3 minutes express the air out of the syringe. Remove the blue valve and place the dispensing tip on the syringe. Inject the graft material into the socket beginning at the apex filling to the gingival margin. |
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Regen Biocement is also available in six, sterile, single-use packets ready for use in the sterile surgical field. (Hydrase, the wetting agent is needed for this order). |
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REGEN BIOCEMENT is constituted with HYDRASE™ bone graft wetting agent. HYDRASE is an ideal bone graft wetting agent for all bone graft materials and for implant wetting prior to insertion. HYDRASE meets USP standards for water for irrigation and is specifically formulated to provide the optimum pH, ion conductivity, and ion content for osteoblastic activity. |
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| In this photo a monoject syringe is used to graft this patient’s severe lesions. Injecting from the depth of the lesion ensures complete fill and the monoject syringe permits a large area to be grafted quickly and effectively. |
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The innovative properties of REGEN BIOCEMENT permits innovative surgical modalities to better serve your patients and your practice. |
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| REGEN BIOCEMENT™ AND PERIODONTAL REGENERTAION |
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| Severely involved molars were grafted with REGEN BIOCEMENT and covered with an Inverted Periosteal Graft™. |
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| The mesial lesion on #30 is a one wall defect that wrapped around the lingual surface into a lingual class two furcation. |
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| The previous lesions are now filled with dense bone. Probings are 3mm or less. The mesial surface of this molar was biopsied and regrafted. |
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| The photomicrograph from the above molar shows the attachment apparatus on the left stained blue/green. The blue arrows identify remaining bone graft particles imbedded in the regenerated bone. REGEN BIOCEMENT is an ideal grafting material for all forms of periodontal surgical procedures. |
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| This photo illustrates the Inverted Periosteal Graft™. The buccal periosteum is inverted with the apical portion of the periosteum sutured to the apical portion of the lingual periosteum. The papilla is reflected between the bicuspids exposing REGEN BIOCEMENT after grafting. |
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| In this photo the buccal and lingual periosteum is sutured interproximally prior to grafting. The monoject syringe is inserted under the lingual periosteum and the osseous lesions are quickly and easily grafted with REGEN BIOCEMENT. |
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| This patient presented with a moderate 3 wall defect mesial #19, a severe interproximal 2 wall defect between 18 and 19 with probing close to the apex and a class two buccal furcation on #18. |
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| Seven months after grafting with REGEN BIOCEMENT all lesions are resolved with all probing 3mm or less. |
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| The mesial of #14 presented with a class two furcation. |
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The post operative radiograph shows regeneration of the furcation and the mesial lesion.
The Inverted Periosteal Graft™ is the intellectual property of STEINER LABORATORIES. Permission for the use of this surgical procedure is granted when using REGEN BIOCEMENT as the bone graft material.
Click here for a photo essay on the Inverted Periosteal Graft™. |
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| REGEN BIOCEMENT™ AND REGENERATION OF HORIZONTAL BONE LOSS |
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The preoperative radiographs show significant horizontal bone loss with vertical defects mesial of both canines. Probings are between 6 and 8mm.The lesions were treated with REGEN BIOCEMENT mixed with a particulate bone graft material in order to maintain space. The compound graft was covered with an Inverted Periosteal Graft. |
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Six weeks post op shows all vertical defects filled and approximatly 3mm appositional horizontal bone regeneration. |
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At six weeks the gingival margins are maintained and all probings are 3 mm or less. |
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| REGEN BIOCEMENT™ AND THE STEINER SINUS LIFT™ |
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| A crestal incision is made to expose the buccal maxilla. Radiographic measurements are used to locate the floor of the sinus and a #10 round burr perforates the lateral wall of the sinus. |
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O osteoid-like bone lining, M sinus membrane, B bone The micropaddle is approximately 1mm in diameter.
The osteotomy is commonly 2-3 mm deep and 3-4 mm is diameter to reach the sinus membrane. A 1mm micropaddle (Steiner Laboratories) is pressed onto the osteoid-like layer or the sinus membrane and slipped between the membrane and bone. The micropaddle is used to separate the membrane from bone for about 5 millimeters around the osteotomy. |
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| After the membrane has been release from around the osteotomy a microball (Steiner Laboratories) is used to further release the membrane mesial and distal to the osteotomy and to separate the membrane from the floor of the sinus and across to the medial wall of the sinus. As long as the micropaddle and the microball stay in contact with bone the membrane will not be damaged. |
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| A monoject syringe loaded with REGEN BIOCEMENT delivers the graft material. As the graft material is injected the sinus raises under hydraulic pressure. The amount of sinus lift is determined by the amount of graft material injected. |
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| This patient shows typical poor bone density with a low maxillary sinus. Due to the fact that REGEN BIOCEMENT adheres to the implant and supports the implant during integration, there is no minimum amount of bone required to place implants at the time of sinus lift grafting. |
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| At three months the maxillary alveolar ridge has grown apically and the floor of the sinus is filled with dense bone. The bone in the grafted sinus has more radiodensity than the preexisting alveolar ridge. Three months after the sinus lift the implants are ready for restoration. |
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The Steiner Sinus Lift™ is atraumatic. Typically, patients are unaware the sinus has been grafted. Perforation of the Sniderian membrane has not occurred when using the Steiner Sinus Lift™.
Restorative dentistry courtesy of Dr. Ron Ask. |
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This photomicrograph is a bone core sample from a sinus. The sinus had been grafted with REGEN BIOCEMENT using the Steiner Sinus Lift™.
The Steiner Sinus Lift™ is the intellectual property of STEINER LABORATORIES. Permission to use this surgery is granted when using REGEN BIOCEMENT.
Click here for a photo essay on the Steiner Sinus Lift™. |
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| REGEN BIOCEMENT™ AND COMBINATION OSSEOUS LESIONS |
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Fractured #4 and pneumatized sinus. |
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Severe alveolar loss from the fractured tooth and a pneumatized sinus leaves a shell of bone between #2 and #5. The sinus is augmented using the Steiner Sinus Lift and REGEN BIOCEMENT. The osteotomy for the sinus lift can be seen to the left of the photomicrograph filled with REGEN BIOCEMENT. The alveolar ridge is also grafted with REGEN BIOCEMENT. The surgical site is closed and no membranes are used. |
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At three months new bone formation on the regenerated ridge is complete and both the sinus and alveolar ridge are ready for implant placement. |
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Six months after extraction of tooth #4 the implants are ready for restoration. |
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Fully restored, both implants are supported by regenerated bone. |
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Buccal view of restored implants #3 and #4. |
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Occlusal view of regenerated alveolar ridge. |
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Lingual view of regenerated alveolar ridge. |
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| WHAT CAN YOUR BONE GRAFT DO FOR YOU? |
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| For more surgical innovations using REGEN BIOCEMENT, click on the following: |
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